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Hear Res. 2018 Mar;360:40-54. doi: 10.1016/j.heares.2017.12.016. Epub 2017 Dec 28.

A phenomenological model of the synapse between the inner hair cell and auditory nerve: Implications of limited neurotransmitter release sites.

Author information

1
Department of Electrical & Computer Engineering, McMaster University, Hamilton, ON, Canada. Electronic address: ibruce@ieee.org.
2
Department of Electrical & Computer Engineering, McMaster University, Hamilton, ON, Canada. Electronic address: erfani.yousof@gmail.com.
3
Department of Computer Engineering, University of Hail, Hail, Saudi Arabia. Electronic address: msazilany@gmail.com.

Abstract

Peterson and Heil [Hear. Res., In Press] have argued that the statistics of spontaneous spiking in auditory nerve fibers (ANFs) can be best explained by a model with a limited number of synaptic vesicle docking (release) sites (∼4) and a relatively-long average redocking time (∼16-17 ms) for each of the sites. In this paper we demonstrate how their model can be: i) generalized to also describe sound-driven ANF responses and ii) incorporated into a well-established and widely-used model of the entire auditory periphery [Zilany et al., J. Acoust. Soc. Am. 135, 283-286, 2014]. The responses of the new model exhibit substantial improvement in several measures of ANF spiking statistics, and predicted physiological forward-masking and rate-level functions from the new model structure are shown to also better match published physiological data.

KEYWORDS:

Auditory model; Neurotransmitter vesicle release; Refractoriness; Renewal process; Spike timing statistics; Synapse

PMID:
29395616
DOI:
10.1016/j.heares.2017.12.016
[Indexed for MEDLINE]

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