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Clin Investig Arterioscler. 2018 Mar - Apr;30(2):64-71. doi: 10.1016/j.arteri.2017.10.003. Epub 2018 Feb 1.

Evaluation of non-HDL cholesterol as a predictor of non-fatal cardiovascular events in a prospective population cohort.

[Article in English, Spanish]

Author information

1
Unidad de Lípidos, Hospital Quirónsalud, Albacete, España; Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan de Alicante, Alicante, España; Cátedra de Riesgo Cardiovacular, Universidad Católica de San Antonio (UCAM), Murcia, España. Electronic address: julio.carbayo.herencia@gmail.com.
2
Medicina Familiar y Comunitaria, Centro de Salud «Zona IV», Albacete, España.
3
Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan de Alicante, Alicante, España.
4
Medicina Familiar y Comunitaria, Centro de Salud Casas Ibáñez, Casas Ibáñez, Albacete, España.
5
Medicina Familiar y Comunitaria, Centro de Salud Ayna, Ayna, Albacete, España.
6
Medicina Familiar y Comunitaria, Centro de Salud de Villacerrada, Villacerrada, Albacete, España.
7
Servicio de Radiodiagnóstico, Hospital General de Almansa, Almansa, Albacete, España.
8
Medicina Familiar y Comunitaria, Centro de Salud Casas Ibáñez, Casas Ibáñez, Albacete, España; Cátedra de Medicina Familiar y Comunitaria, Grado de Medicina, UCAM, Murcia, España.

Abstract

INTRODUCTION:

Non-HDL cholesterol (non-HDL-C) is becoming relevant both in its participation in cardiovascular risk assessment and as a therapeutic target. The objective of the present study was to assess the independent predictive capacity of both non-HDL-C and LDL-C (the main priority in dyslipidemias to reduce cardiovascular risk), in cardiovascular morbidity in a population-based sample.

METHODS:

A prospective cohort study involving 1186 individuals in the non-HDL-C group and 1177 in the LDL-C group, followed for 10.7years (SD=2.2), who had not had any previous cardiovascular event. The predictor variables included in the adjustment were: gender, age, arterial hypertension, diabetes mellitus, smoker status and non-HDL-C in one group. In the other group, consisting of patients presenting TG levels of 400mg/dL, non-HDL-C was replaced by LDL-C. Survival curves (Kaplan-Meier) were calculated and two Cox regression models were applied, one for each group.

RESULTS:

Non-HDL-C group presented 6.2% of non-fatal cardiovascular episodes during follow-up and the LDL-C group 6.0%. After adjustment, for each 30mg/dL increase in non-HDL-C, the incidence of new non-fatal cardiovascular events increased by 31% (HR=1.31, 95%CI: 1.06-1.61; P=.018) and in the LDL-C group by 27% (HR=1.27, 95%CI: 0.97-1.61, P=.068).

CONCLUSIONS:

After a follow-up of 10.7years, non-HDL-C has been shown in our population as a prognostic factor of non-fatal cardiovascular disease, but not LDL-C, although its HR is close to statistical significance.

KEYWORDS:

Aterosclerosis; Atherosclerosis; Cardiovascular diseases; Cohort studies; Enfermedad cardiovascular; Estudio de cohortes; Factores de riesgo; Morbidity; Morbilidad; Risk factors

PMID:
29395492
DOI:
10.1016/j.arteri.2017.10.003
[Indexed for MEDLINE]

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