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J Biomech. 2018 Mar 1;69:26-33. doi: 10.1016/j.jbiomech.2018.01.014. Epub 2018 Jan 16.

Original article submission: Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney.

Author information

1
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
2
SimuTech Group, Rochester, NY, USA.
3
Department of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
4
Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA.
5
Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
6
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
7
Department of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Electronic address: shuvo.roy@ucsf.edu.

Abstract

An implantable artificial kidney using a hemofilter constructed from an array of silicon membranes to provide ultrafiltration requires a suitable blood flow path to ensure stable operation in vivo. Two types of flow paths distributing blood to the array of membranes were evaluated: parallel and serpentine. Computational fluid dynamics (CFD) simulations were used to guide the development of the blood flow paths. Pressure data from animal tests were used to obtain pulsatile flow conditions imposed in the transient simulations. A key consideration for stable operation in vivo is limiting platelet stress accumulation to avoid platelet activation and thrombus formation. Platelet stress exposure was evaluated by CFD particle tracking methods through the devices to provide distributions of platelet stress accumulation. The distributions of stress accumulation over the duration of a platelet lifetime for each device revealed that stress accumulation for the serpentine flow path exceeded levels expected to cause platelet activation while the accumulated stress for the parallel flow path was below expected activation levels.

KEYWORDS:

Artificial kidney; Hemodynamics; Platelet stress accumulation; Thrombogenicity

PMID:
29395231
PMCID:
PMC5809289
DOI:
10.1016/j.jbiomech.2018.01.014
[Indexed for MEDLINE]
Free PMC Article

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