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Cell Stem Cell. 2018 Feb 1;22(2):148-150. doi: 10.1016/j.stem.2018.01.005.

Shaping the Pluripotent Genome: Switches, Borders, and Loops.

Author information

1
Joan & Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: efa2001@med.cornell.edu.

Abstract

Three-dimensional genome organization is largely cell type specific and requires reorganization during cell fate transitions. A recent study in Nature Genetics (Stadhouders et al., 2018) offers important insights into the principles and drivers of such reorganization during reprogramming of somatic cells into pluripotent stem cells.

PMID:
29395051
DOI:
10.1016/j.stem.2018.01.005
[Indexed for MEDLINE]
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