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J Orthop Surg Res. 2018 Feb 2;13(1):27. doi: 10.1186/s13018-018-0717-1.

Risk factors for non-fusion segment disease after anterior cervical spondylosis surgery: a retrospective study with long-term follow-up of 171 patients.

Author information

1
Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
2
Department of Orthopedics, The First Affiliated Hospital of the General Hospital of PLA, Beijing, 100048, People's Republic of China.
3
Department of Orthopedics, The First Affiliated Hospital of the General Hospital of PLA, Beijing, 100048, People's Republic of China. rendfspine@163.com.
4
Department of Orthopedics, The First Affiliated Hospital of the General Hospital of PLA, Beijing, 100048, People's Republic of China. tangjiaguang2013@163.com.

Abstract

BACKGROUND:

The purpose of this study was to investigate the incidence and causes of non-fusion segment disease (NFSD), both adjacent and non-adjacent to a fused segment, after anterior cervical arthrodesis.

METHODS:

This is a single-center study. Between January 1998 and January 2011, two surgeons' 171 patients who had an anterior cervical decompression and fusion were followed clinically for more than 5 years. The correlation between the incidence of symptomatic non-fusion segment disease and the following clinical parameters (age at operation, fusion levels,) and radiological parameters (number of patients who had a plate, anterior cervical decompression and fusion (ACDF) or corpectomies, preoperative and postoperative cervical spine alignment, Pavlov's ratio at the C5 level, and preoperative existence of a non-fusion segment degeneration on magnetic resonance imaging) was evaluated.

RESULTS:

Of the 171 patients reviewed, 16 patients had non-fusion segment disease (9.36%), of which 12 had adjacent segment disease and 4 had non-adjacent segment disease. Postoperative cervical lordosis in the non-fusion segment disease group was significantly smaller than that of the disease-free group (P < 0.001). Fusion levels in the NFSD group were 1.69 whereas 2.26 in disease-free group (P = 0.005). The incidences of disc degeneration in unfused segments was more severe in the NFSD group than in the disease-free group (P = 0.004). The results of binary logistic regression showed that the major factor affecting NFSD is postoperative cervical lordosis (P = 0.000) followed by disc degeneration (P = 0.024). The other parameters did not show a statistically significant difference.

CONCLUSIONS:

The incidence of symptomatic non-fusion segment disease after anterior cervical arthrodesis has multifactorial causes. Postoperative cervical lordosis and disc degeneration in non-fusion segments were major factors in the incidence of NFSD.

KEYWORDS:

Adjacent segment disease; Anterior cervical arthrodesis; Cervical spondylosis; Non-fusion segment disease

PMID:
29394936
PMCID:
PMC5797381
DOI:
10.1186/s13018-018-0717-1
[Indexed for MEDLINE]
Free PMC Article

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