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Pediatr Int. 2018 May;60(5):418-422. doi: 10.1111/ped.13526. Epub 2018 Mar 30.

Etiology and antimicrobial resistance patterns in pediatric urinary tract infection.

Author information

1
Department of Urology, Children's Hospital of Nanjing Medical University, Nanjing, China.
2
Department of Clinical Laboratory, Children's Hospital of Nanjing Medical University, Nanjing, China.
3
School of Rehabilitation Medicine, Nanjing Medical University, Nanjing, China.

Abstract

BACKGROUND:

Urinary tract infection (UTI) is one of most common pediatric infections. The aim of this study was to investigate the etiology and antimicrobial resistance patterns in children hospitalized at Children's Hospital of Nanjing Medical University.

METHODS:

We conducted a retrospective, descriptive study of all UTI from 1 January 2013 to 30 November 2016 in children discharged from Nanjing Children's Hospital. The isolated pathogens and their resistance patterns were examined using midstream urine culture.

RESULTS:

A total of 2,316 children with UTI were included in the study. The occurrence rates of isolated pathogens were as follows: Enterococcus spp., 35.15%; Escherichia coli, 22.32%; Staphylococcus aureus spp., 7.73%; Streptococcus spp., 7.51%; and Klebsiella spp., 6.95%. Uropathogens had a low susceptibility to linezolid (3.47%), vancomycin (0.92%), imipenem (5.74%), and amikacin (3.17%), but they had a high susceptibility to erythromycin (90.52%), penicillin G (74.01%), cefotaxime (71.41%), cefazolin (73.41%), cefuroxime (72.52%), and aztreonam (70.11%).

CONCLUSIONS:

There is high antibiotic resistance in hospitalized children with UTI. Susceptibility testing should be carried out on all clinical isolates, and the empirical antibiotic treatment should be altered accordingly.

KEYWORDS:

etiology; ntibiotic resistance; pediatrics; urinary tract infection

PMID:
29394522
DOI:
10.1111/ped.13526
[Indexed for MEDLINE]

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