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Angew Chem Int Ed Engl. 2018 Mar 26;57(14):3626-3630. doi: 10.1002/anie.201712528. Epub 2018 Feb 28.

Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission.

Author information

1
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
2
Division of Physical Biology & Bioimaging Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, P. R. China.
3
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.

Abstract

Fluorescent probes in the second near-infrared window (NIR-II) allow high-resolution bioimaging with deep-tissue penetration. However, existing NIR-II materials often have poor signal-to-background ratios because of the lack of target specificity. Herein, an activatable NIR-II nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H2 S-activated ratiometric fluorescence and light-up NIR-II emission at 900-1300 nm. By using this activatable and target specific probe for deep-tissue imaging of H2 S-rich colon cancer cells, accurate identification of colorectal tumors in animal models were performed. It is anticipated that the development of activatable NIR-II probes will find widespread applications in biological and clinical systems.

KEYWORDS:

colon cancer; fluorescence; in vivo imaging; nanoprobes; second near-infrared window

PMID:
29393566
DOI:
10.1002/anie.201712528

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