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Diabetes Metab Res Rev. 2018 May;34(4):e2986. doi: 10.1002/dmrr.2986. Epub 2018 Mar 15.

Ten-year weight gain is associated with elevated fasting insulin levels and precedes glucose elevation.

Author information

1
Department of Family Medicine, Campbell University School of Osteopathic Medicine, Buies Creek, NC, USA.
2
Campbell University School of Osteopathic Medicine, Buies Creek, NC, USA.
3
Department of Public Health, Campbell University College of Pharmacy and Health Sciences, Buies Creek, NC, USA.

Abstract

BACKGROUND:

Numerous studies have examined the relationship between endogenous insulin and weight change with mixed results. This study examined the relationship between fasting insulin levels, insulin resistance (IR), and 10-year weight change by glycaemic stage.

METHODS:

Using data from the US National Health and Nutrition Examination Survey 2011-2014, 3840 participants were divided into 6 groups based on fasting glucose and fasting insulin levels. Fasting insulin concentrations were dichotomized into <25th percentile (normal) and ≥25th percentile (elevated). Ten-year weight change associated with fasting insulin was assessed by glycaemic stage.

RESULTS:

Average weight change over a 10-year period was higher in individuals with elevated insulin levels compared to the first quartile (1.40 lbs. vs 11.12 lbs, P < .0001). Across all groups, a 1 μU increase in fasting insulin levels resulted in a 0.52-pound increase in weight (P < .0001). Similarly, an increase in HOMA-IR was associated with increase in weight (1.32 lbs per IR unit, P < .0001). Marginal increases in weight were most pronounced in the normal insulin groups compared to elevated insulin groups and diminished as glycaemic stage progressed.

CONCLUSIONS:

Elevated fasting insulin level was positively associated with weight gain. The impact of fasting insulin and IR on weight gain preceded hyperglycaemia and diminished as glycaemic stage progressed.

KEYWORDS:

hyperglycaemia; insulin; insulin resistance; weight change; weight gain

PMID:
29392827
DOI:
10.1002/dmrr.2986
[Indexed for MEDLINE]

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