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Adv Exp Med Biol. 2018;1067:89-108. doi: 10.1007/5584_2017_140.

Circulating Biomarkers in Heart Failure.

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Internal Medicine Department, State Medical University of Zaporozhye, Zaporozhye, Ukraine.


Biological markers have served for diagnosis, risk stratification and guided therapy of heart failure (HF). Our knowledge regarding abilities of biomarkers to relate to several pathways of HF pathogenesis and reflect clinical worsening or improvement in the disease is steadily expanding. Although there are numerous clinical guidelines, which clearly diagnosis, prevention and evidence-based treatment of HF, a strategy regarding exclusion of HF, as well as risk stratification of HF, nature evolution of disease is not well established and requires more development. The aim of the chapter is to discuss a role of biomarker-based approaches for more accurate diagnosis, in-depth risk stratification and individual targeting in treatment of patients with HF.


Biomarker guided-therapy; Biomarkers; Heart failure; Prediction; Stratification

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