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J Cardiovasc Transl Res. 2018 Jun;11(3):173-181. doi: 10.1007/s12265-018-9785-1. Epub 2018 Feb 1.

Retrograde Coronary Venous Infusion as a Delivery Strategy in Regenerative Cardiac Therapy: an Overview of Preclinical and Clinical Data.

Author information

1
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
2
Regenerative Medicine Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
3
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. S.A.J.Chamuleau@umcutrecht.nl.
4
Regenerative Medicine Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands. S.A.J.Chamuleau@umcutrecht.nl.

Abstract

An important aspect of cell therapy in the field of cardiac disease is safe and effective delivery of cells. Commonly used delivery strategies such as intramyocardial injection and intracoronary infusion both present with advantages and disadvantages. Therefore, alternative delivery routes are explored, such as retrograde coronary venous infusion (RCVI). Our aim is to evaluate safety and efficiency of RCVI by providing a complete overview of preclinical and clinical studies applying RCVI in a broad range of disease types and experimental models. Available data on technical and safety aspects of RCVI are incomplete and insufficient. Improvement of cardiac function is seen after cell delivery via RCVI. However, cell retention in the heart after RCVI appears inferior compared to intracoronary infusion and intramyocardial injection. Adequately powered confirmatory studies on retention rates and safety are needed to proceed with RCVI in the future.

KEYWORDS:

Cell therapy; Heart failure; Myocardial infarction; Retrograde coronary venous infusion

PMID:
29392536
PMCID:
PMC5973989
DOI:
10.1007/s12265-018-9785-1
[Indexed for MEDLINE]
Free PMC Article

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