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Aging Dis. 2018 Feb 1;9(1):143-150. doi: 10.14336/AD.2017.0306. eCollection 2018 Feb.

A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly.

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1Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, PA 19141, USA.
2Department of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
3Division of Nephrology, Department of Medicine, Einstein Medical Center, Philadelphia, PA 19144, USA.


NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation; however, NSAIDs are known for multiple adverse effects, including gastrointestinal bleeding, cardiovascular side effects, and NSAID induced nephrotoxicity. As our society ages, it is crucial to have comprehensive knowledge of this class of medication in the elderly population. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, current guidelines for NSAIDs use, adverse effect profile, and drug interaction of NSAIDs and commonly used medications in the elderly.


NSAIDs; Non-steroidal anti-inflammatory drug; elderly; geriatric conditions; pleiotropic effects

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