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Parasit Vectors. 2018 Feb 1;11(1):75. doi: 10.1186/s13071-018-2616-z.

Economic evaluations of lymphatic filariasis interventions: a systematic review and research needs.

Author information

1
School of Public Health, Faculty of Medicine, St Marys Campus, Imperial College London, Norfolk Place, London, W2 1PG, UK.
2
London Centre for Neglected Tropical Disease Research, London, UK.
3
Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Marys Campus, Imperial College London, Norfolk Place, London, W2 1PG, UK.
4
Global Health Programs, GlaxoSmithKline, Brentford, UK.
5
Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK.
6
School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
7
Big Data Institute, University of Oxford, Oxford, OX3 7LF, UK.
8
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam. hturner@oucru.org.
9
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. hturner@oucru.org.

Abstract

In 2000, the World Health Organization established the Global Programme to Eliminate Lymphatic Filariasis (GPELF), with the goal of eliminating the disease as a public health problem by 2020. Since the start of the programme, a cumulative total of 6.2 billion treatments have been delivered to affected populations - with more than 556 million people treated in 2015 alone. In this paper, we perform a rigorous systematic review of the economic evaluations of lymphatic filariasis interventions have been conducted. We demonstrate that the standard interventions to control lymphatic filariasis are consistently found to be highly cost-effective. This finding has important implications for advocacy groups and potential funders. However, there are several important inconsistencies and research gaps that need to be addressed as we move forward towards the 2020 elimination goals. One of the most important identified research gaps was a lack of evaluation of new interventions specifically targeting areas co-endemic with onchocerciasis and Loa loa - which could become a major barrier to achieving elimination.

KEYWORDS:

Cost-benefit; Cost-effectiveness; Economic evaluations; Economic impact; GPELF; Lymphatic filariasis; Programme evaluation

PMID:
29391042
PMCID:
PMC5793442
DOI:
10.1186/s13071-018-2616-z
[Indexed for MEDLINE]
Free PMC Article

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