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J Food Drug Anal. 2018 Jan;26(1):14-20. doi: 10.1016/j.jfda.2017.10.004. Epub 2017 Nov 11.

Stem cell therapy on skin: Mechanisms, recent advances and drug reviewing issues.

Author information

1
Center for Drug Evaluation, Taipei 11557, Taiwan; Department of Dermatology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; Department of Dermatology, Kang-Ning General Hospital, Taipei 11490, Taiwan.
2
Department of Speech Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei 11219, Taiwan.
3
Center for Drug Evaluation, Taipei 11557, Taiwan.
4
Center for Drug Evaluation, Taipei 11557, Taiwan; Department of Speech Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei 11219, Taiwan. Electronic address: smweng671@cde.org.tw.

Abstract

Stem cell products and its clinical applications have been widely discussed in recent years, particularly when the Japanese "induced pluripotent stem cells" founder Dr. Yamanaka was awarded as Nobel Prize laureate in 2013. For decades, major progresses have been achieved in the stem cell biology field, and more and more evidence showed that skin stem cells are involved in the process of skin repair. Stem/progenitor cells of the epidermis are recognized to play the most essential role in the tissue regeneration of skin. In this review, we first illustrated basic stem cell characteristics and various stem cell subtypes resided in the skin. Second, we provided several literatures to elucidate how stem/progenitor cells collaborate in the process of skin repair with the evidence from animal model studies and in vitro experiments. Third, we also introduced several examples of skin cell products on the pharmaceutic market and the ongoing clinical trials aiming for unmet medical difficulties of skin. Last but not least, we summarized general reviewing concerns and some disputatious issues on dermatological cell products. With this concise review, we hope to provide further beneficial suggestions for the development of more effective and safer dermatological stem/progenitor cell products in the future.

KEYWORDS:

Cell therapy; Dermatology; Drug reviewing

PMID:
29389549
DOI:
10.1016/j.jfda.2017.10.004
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