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Adv Mater. 2018 Mar;30(12):e1706887. doi: 10.1002/adma.201706887. Epub 2018 Feb 1.

Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors.

Author information

1
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China.
2
Division of Physical Biology and Bioimaging Center College of Life Sciences, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, P. R. China.
3
Department of Pharmaceutical Science, Åbo Akademic University, FI-20520, Turku, Finland.
4
Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, P. R. China.
5
Institutes of Biomedical Sciences and Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.

Abstract

Conducting hydrogels provide great potential for creating designer shape-morphing architectures for biomedical applications owing to their unique solid-liquid interface and ease of processability. Here, a novel nanofibrous hydrogel with significant enzyme-like activity that can be used as "ink" to print flexible electrochemical devices is developed. The nanofibrous hydrogel is self-assembled from guanosine (G) and KB(OH)4 with simultaneous incorporation of hemin into the G-quartet scaffold, giving rise to significant enzyme-like activity. The rapid switching between the sol and gel states responsive to shear stress enables free-form fabrication of different patterns. Furthermore, the replication of the G-quartet wires into a conductive matrix by in situ catalytic deposition of polyaniline on nanofibers is demonstrated, which can be directly printed into a flexible electrochemical electrode. By loading glucose oxidase into this novel hydrogel, a flexible glucose biosensor is developed. This study sheds new light on developing artificial enzymes with new functionalities and on fabrication of flexible bioelectronics.

KEYWORDS:

enzyme mimicking; flexible electrochemical sensors; guanosine; low-molecular-weight hydrogels; self-assembly

PMID:
29388269
DOI:
10.1002/adma.201706887
[Indexed for MEDLINE]

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