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Food Sci Nutr. 2017 Nov 20;6(1):197-206. doi: 10.1002/fsn3.547. eCollection 2018 Jan.

Effects of 3 months continuous intake of supplement containing Pantoea agglomerans LPS to maintain normal bloodstream in adults: Parallel double-blind randomized controlled study.

Author information

Macrophi Inc.Takamatsu Kagawa Japan.
Department of Integrated and Holistic Immunology Faculty of Medicine Kagawa University Miki-cho, Kida-gun Kagawa Japan.
Non-profit Organization, Linking Setouchi Innate Immune Network Takamatsu Kagawa Japan.
Central Park ClinicTakamatsu Kagawa Japan.
Nakagawa Hospital Fukuoka Japan.
Niigata University of Pharmacy and Applied Life Sciences Research Organization of Health for Self-Reliance Niigata Japan.


In this study, the effects on the maintenance of normal bloodstream by lipopolysaccharide (LPS) were investigated in the parallel-group randomized double-blind study using supplement containing Pantoea agglomerans LPS (201.5 μg/tablet as LPS). Screening was previously performed in the implementation of the study. Adult males and females with normal value to borderline (healthy subjects) in the hematologic parameters, for which reference values were given, were chosen in this study. The period of ingestion of the supplement was 3 months. As the result, a significant decrease in the rate of change (the ratio when the baseline was 1) of HbA1c, which is a glycative stress marker, was found in the group which ingested LPS supplement after 3 months. Also, a significant increase in the number of fingertip capillary vessels was found compared with the control group. From these results, the effects of the maintenance of bloodstream by ingestion of LPS were shown.


arteriosclerosis; glycative stress; lipopolysaccharide; macrophage; vessel

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