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Skelet Muscle. 2018 Jan 31;8(1):3. doi: 10.1186/s13395-017-0149-3.

Myoblast fusion confusion: the resolution begins.

Author information

1
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA, 92121, USA. hsampath@gnf.org.
2
Division of Musculoskeletal Imaging, Department of Radiology, University of California San Diego School of Medicine, 200 West Arbor Drive, San Diego, CA, 92103, USA. hsampath@gnf.org.
3
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA, 92121, USA. ssampath@gnf.org.
4
Division of Musculoskeletal Imaging, Department of Radiology, University of California San Diego School of Medicine, 200 West Arbor Drive, San Diego, CA, 92103, USA. ssampath@gnf.org.
5
Department of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH, 45229, USA. douglas.millay@cchmc.org.
6
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA. douglas.millay@cchmc.org.

Abstract

The fusion of muscle precursor cells is a required event for proper skeletal muscle development and regeneration. Numerous proteins have been implicated to function in myoblast fusion; however, the majority are expressed in diverse tissues and regulate numerous cellular processes. How myoblast fusion is triggered and coordinated in a muscle-specific manner has remained a mystery for decades. Through the discovery of two muscle-specific fusion proteins, Myomaker and Myomerger-Minion, we are now primed to make significant advances in our knowledge of myoblast fusion. This article reviews the latest findings regarding the biology of Myomaker and Minion-Myomerger, places these findings in the context of known pathways in mammalian myoblast fusion, and highlights areas that require further investigation. As our understanding of myoblast fusion matures so does our potential ability to manipulate cell fusion for therapeutic purposes.

KEYWORDS:

Minion; Muscle development; Myoblast fusion; Myomaker; Myomerger

PMID:
29386054
PMCID:
PMC5793351
DOI:
10.1186/s13395-017-0149-3
[Indexed for MEDLINE]
Free PMC Article

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