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Neurosurg Focus. 2018 Feb;44(2):E11. doi: 10.3171/2017.11.FOCUS17613.

Magnetic resonance-guided interstitial high-intensity focused ultrasound for brain tumor ablation.

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Departments of 1 Neuroscience and Experimental Therapeutics and.
Neurosurgery, Albany Medical Center, Albany, New York.
Robotics Engineering Program, Worcester Polytechnic Institute, Worcester, Massachusetts; and.
Acoustic MedSystems, Inc., Savoy, Illinois.


Currently, treatment of brain tumors is limited to resection, chemotherapy, and radiotherapy. Thermal ablation has been recently explored. High-intensity focused ultrasound (HIFU) is being explored as an alternative. Specifically, the authors propose delivering HIFU internally to the tumor with an MRI-guided robotic assistant (MRgRA). The advantage of the authors' interstitial device over external MRI-guided HIFU (MRgHIFU) is that it allows for conformal, precise ablation and concurrent tissue sampling. The authors describe their workflow for MRgRA HIFU delivery.


DOF = degrees of freedom; GBM = glioblastoma; HIFU = high-intensity focused ultrasound; LITT = laser interstitial thermal therapy; MRI guided; MRIT = MRI thermometry; MRgHIFU = MRI-guided HIFU; MRgRA = MRI-guided robot assistant; SRS = stereotactic radiosurgery; brain tumor; high-intensity focused ultrasound; neural ablation

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