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Crit Rev Biotechnol. 2018 Nov;38(7):1049-1060. doi: 10.1080/07388551.2018.1428167. Epub 2018 Feb 1.

Fatty acids from oleaginous yeasts and yeast-like fungi and their potential applications.

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a College of Marine Life Sciences , Ocean University of China , Qingdao , China.
b Laboratory for Marine Biology and Biotechnology , Qingdao National Laboratory for Marine Science and Technology , Qingdao , China.
c Department of Biology , Shantou University , Shantou , China.



Oleaginous yeasts, fatty acids biosynthesis and regulation in the oleaginous yeasts and the fatty acids from the oleaginous yeasts and their applications are reviewed in this article.


Oleaginous yeasts such as Rhodosporidium toruloides, Yarrowia lipolytica, Rhodotorula mucilaginosa, and Aureobasidium melanogenum, which can accumulate over 50% lipid of their cell dry weight, have many advantages over other oleaginous microorganisms. The fatty acids from the oleaginous yeasts have many potential applications. Many oleaginous yeasts have now been genetically modified to over-produce fatty acids and their derivatives. The most important features of the oleaginous yeasts are that they have special enzymatic systems for enhanced biosynthesis and regulation of fatty acids in their lipid particles. Recently, some oleaginous yeasts such as R. toruloides have been found to have a unique fatty acids synthetase and other oleaginous yeasts such as A. melanogenum have a unique highly reducing polyketide synthase (HR-PKS) involved in the biosynthesis of hydroxyl fatty acids.


It is necessary to further enhance lipid biosynthesis using metabolic engineering and explore new applications of fatty acids in biotechnology.


Oleaginous yeasts; fatty acids; industrial applications; lipid particle; triacylglycerols

[Indexed for MEDLINE]

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