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Nutrients. 2018 Jan 30;10(2). pii: E152. doi: 10.3390/nu10020152.

Database Analysis of Depression and Anxiety in a Community Sample-Response to a Micronutrient Intervention.

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Pure North S'Energy Foundation, Calgary, AB T2R 0C5, Canada.
Department of Natural and Mathematical Sciences, St. Mary's University, Calgary, AB T2X 1Z4, Canada.
Pure North S'Energy Foundation, Calgary, AB T2R 0C5, Canada.
Department of Psychology, University of Canterbury, Christchurch 8140, New Zealand.



Depression and anxiety are common mental health concerns worldwide. Broad-spectrum multi-vitamin/mineral approaches have been found to alleviate a number of psychiatric symptoms. We investigated the effects of a nutrient intervention program, which includes optimizing vitamin D levels, on depression and anxiety outcomes from community-based program.


We evaluated self-reported health measures of depression and anxiety collected as part of a community-based program focused on optimizing overall health through nutritional supplementation, education and lifestyle advice.


Data were collected from 16,020 participants, with measures including European Quality of Life Five Dimensions (EQ-5D) and Targeted Symptoms List (TSL) providing self-reported depression and anxiety. More than 56% of participants were identified as having elevated levels of depression and anxiety at baseline as reported on the EQ-5D. After one year in the program, 49.2% (n = 7878) of participants who reported any level of depression or anxiety at baseline reported improvement at follow-up. Of those who reported severe/extreme depression at baseline (n = 829), 97.2% reported improvement after one year. Regression analyses revealed a significant association of improvement in depression and anxiety with higher vitamin D status (>100 nmol/L) and more strenuous physical activity.


Overall, people from the general population who suffer from mood and anxiety problems may benefit from improved nutritional status achieved with nutritional supplements.


anxiety; depression; mental health; multivitamin/multimineral; nutritional supplements; vitamin D

[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

The authors declare no conflict of interest. There was no funding provided directly for this work. Samantha Kimball and Naghmeh Mirhosseini are employed by the Pure North S’Energy Foundation, a not for profit organization. This affiliation does not alter authors’ adherence to all Journal policies on sharing data and materials. J.R. does not receive any financial compensation from Pure North and is a full-time employee at the University of Canterbury.

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