Format

Send to

Choose Destination
Pediatr Blood Cancer. 2018 Jun;65(6):e26982. doi: 10.1002/pbc.26982. Epub 2018 Jan 31.

Possible involvement of IL-6-producing tissue-resident macrophages in early-onset pericardial effusion pathogenesis after hematopoietic stem cell transplantation.

Author information

1
Department of Pediatrics, Faculty of Medicine, University of Ryukyus, Nishihara, Okinawa, Japan.
2
Department of Hematology and Oncology, Okinawa Prefectural Nanbu Medical Center Children's Medical Center, Arakawa, Okinawa, Japan.

Abstract

PURPOSE:

Pericardial effusion (PE) is a potentially life-threatening complication following hematopoietic stem cell transplantation (HCT). A higher incidence of early-onset PE, unrelated to graft-versus-host disease, before day 100 after HCT has been reported in pediatric patients, but the pathogenic mechanism is poorly understood. Aiming to determine the pathogenesis of early-onset PE in pediatric patients, we analyzed the cytokine concentration and cell population in the pericardial fluid of four pediatric patients with PE.

METHODS:

Between January 2009 and December 2015, four patients requiring pericardiocentesis for clinically significant PE were identified in 60 patients. We evaluated the interleukin-6 (IL-6), interferon-γ, IL-1β, and tumor necrosis factor-α levels in PE. Two patients were available for analysis with intracellular cytokine flow cytometry and a chimerism assay.

RESULTS:

All patients showed the accumulation of pericardial macrophages and high concentrations of IL-6 in PE. Notably, the accumulated pericardial macrophages were CD163+ CD15+ CD14+ cells of host origin that produced IL-6.

CONCLUSION:

These IL-6-producing tissue-resident macrophages may be key players in the pathogenesis of early-onset PE.

KEYWORDS:

allogeneic stem cell transplantation; interleukin-6; macrophages; pericardial effusion

PMID:
29384263
DOI:
10.1002/pbc.26982
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center