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J Autism Dev Disord. 2018 Jun;48(6):2112-2121. doi: 10.1007/s10803-018-3472-6.

Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia.

Author information

1
The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, 5th Floor Wood Center, 3615 Civic Center Blvd, Philadelphia, PA, 19104-4318, USA. danzere@email.chop.edu.
2
The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, 5th Floor Wood Center, 3615 Civic Center Blvd, Philadelphia, PA, 19104-4318, USA.
3
Center for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street Suite 860, Philadelphia, PA, 19104-4318, USA.

Abstract

To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (Pā€‰=ā€‰0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.

KEYWORDS:

Autism diagnostic observation schedule; Autism spectrum disorder; Congenital diaphragmatic hernia; Neurodevelopmental delay; Pulmonary hypertension; Pulmonary hypoplasia

PMID:
29383650
DOI:
10.1007/s10803-018-3472-6

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