Format

Send to

Choose Destination
Pathogens. 2018 Jan 28;7(1). pii: E16. doi: 10.3390/pathogens7010016.

On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts.

Author information

1
School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA. sackman@asu.edu.
2
School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA. susanne.pfeifer@asu.edu.
3
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA. timothy.kowalik@umassmed.edu.
4
School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA. jeffrey.d.jensen@asu.edu.

Abstract

Human cytomegalovirus (HCMV) is a member of the β -herpesvirus subfamily within Herpesviridae that is nearly ubiquitous in human populations, and infection generally results only in mild symptoms. However, symptoms can be severe in immunonaive individuals, and transplacental congenital infection of HCMV can result in serious neurological sequelae. Recent work has revealed much about the demographic and selective forces shaping the evolution of congenitally transmitted HCMV both on the level of hosts and within host compartments, providing insight into the dynamics of congenital infection, reinfection, and evolution of HCMV with important implications for the development of effective treatments and vaccines.

KEYWORDS:

human cytomegalovirus; population genetics; viral evolution

Conflict of interest statement

The authors declare no conflict of interest. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center