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Med Sci Sports Exerc. 2018 Jun;50(6):1249-1257. doi: 10.1249/MSS.0000000000001566.

Exercise Effects on Adipose Tissue Postprandial Lipolysis and Blood Flow in Children.

Yan H1,2,3,4,5, Pierce JR1,4, Myers KB6, Dubose KD4, Dubis GS1,2,4, Tanner CJ1,2,4, Hickner RC1,2,3,4,7,8,9.

Author information

1
Human Performance Laboratory, East Carolina University, Greenville, NC.
2
East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC.
3
Center for Health Disparities, East Carolina University, Greenville, NC.
4
Department of Kinesiology, East Carolina University, Greenville, NC.
5
Department of Exercise and Health Sciences, University of Massachusetts Boston, Boston, MA.
6
Department of Nutrition Science, East Carolina University, Greenville, NC.
7
Department of Physiology, East Carolina University, Greenville, NC.
8
Discipline of Biokinetics, Exercise, and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Westville, SOUTH AFRICA.
9
Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, Florida State University, Tallahassee, FL.

Abstract

Poor suppression of lipolysis and blunted increase in blood flow after meal ingestion in obese adults may indicate resistance to the antilipolytic action of insulin. Exercise may be used to normalize lipolytic responses to food intake by increasing insulin sensitivity.

PURPOSE:

To determine if acute bouts of aerobic exercise and/or excise training alter lipolytic and blood flow responses to food intake in lean (LN) and obese (OB) children.

METHODS:

Sixty-five children (9-11 yr) were randomized into acute exercise (EX: 16 LN and 28 OB) or control (CON: 9 LN and 12 OB) groups that exercised (EX), or rested (CON) between standardized breakfast and lunch. Microdialysis probes were inserted into the subcutaneous abdominal adipose tissue to monitor interstitial glycerol (lipolysis) and blood flow. Changes in interstitial glycerol and nutritive flow were calculated from dialysate samples before and after each meal. A subgroup (OB = 15 and LN = 9) from the acute exercise group underwent 16 wk of aerobic exercise training.

RESULTS:

Poor suppression of lipolysis and a blunted increase in adipose tissue nutritive blood flow in response to breakfast was associated with BMI percentile (r = 0.3, P < 0.05). These responses were normalized at lunch in the OB in the EX (P < 0.05), but not in OB in the CON. Sixteen weeks of exercise training did not improve meal-induced blood flow and marginally altered the antilipolytic response to the two meals (P = 0.06).

CONCLUSIONS:

Daily bouts of acute aerobic exercise should be used to improve the antilipolytic and nutritive blood flow response to a subsequent meal in obese children.

PMID:
29381651
PMCID:
PMC5953784
[Available on 2019-06-01]
DOI:
10.1249/MSS.0000000000001566

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