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Biochemistry. 2018 May 1;57(17):2424-2431. doi: 10.1021/acs.biochem.7b01162. Epub 2018 Jan 30.

P-Bodies: Composition, Properties, and Functions.

Luo Y1,2, Na Z1,2, Slavoff SA1,2,3.

Author information

1
Department of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.
2
Chemical Biology Institute , Yale University , West Haven , Connecticut 06516 , United States.
3
Department of Molecular Biophysics and Biochemistry , Yale University , New Haven , Connecticut 06529 , United States.

Abstract

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets. However, the function of P-bodies in translational repression and/or mRNA decay remains contentious. Here we review recent advances in our understanding of the molecular composition of P-bodies, the interactions and processes that regulate P-body liquid-liquid phase separation (LLPS), and the cellular localization of mRNA decay machinery, in the context of how these discoveries refine models of P-body function.

PMID:
29381060
PMCID:
PMC6296482
DOI:
10.1021/acs.biochem.7b01162
[Indexed for MEDLINE]
Free PMC Article

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