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Curr Drug Metab. 2019;20(1):4-8. doi: 10.2174/1389200219666180129151150.

Cross-regulatory Circuit Between AHR and Microbiota.

Author information

1
State Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China.

Abstract

BACKGROUND:

The gut microbes have a close symbiotic relationship with their host. Interactions between host and the microbiota affect the nutritional, immunological, and physiological status of the host. The Aryl Hydrocarbon Receptor (AHR) is a ligand activated transcription factor that mediates the toxicity of xenobiotics. Recently, the relationship between the gut microbiota and AHR has attracted the attention of many researchers.

METHODS:

We undertook a structured search of bibliographic databases for peer-reviewed research literature.

RESULTS:

We found and reviewed 49 peer-reviewed papers dealing with the major aspects related to the crosstalk between AHR and microbiota. The AHR influences the intestinal microbiota population and mediates host-microbe homeostasis. Interestingly, the gut microbiota also produces ligands of AHR from bacterial metabolism and thereby activates the AHR signaling pathway. Concusion: This review presents current knowledge of the cross-regulatory circuit between the AHR and intestinal microbiota. The findings of this review confirm the importance of AHR-microbiota interactions in health and disease.

KEYWORDS:

Aryl hydrocarbon receptor (AHR); cross-regulatory; homeostasis; ligand; microbiota; xenobiotics.

[Indexed for MEDLINE]

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