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J Biomater Appl. 2018 Apr;32(9):1212-1221. doi: 10.1177/0885328218754615. Epub 2018 Jan 30.

Evaluation of wound healing effect of alginate films containin g Aloe vera ( Aloe barbadensis Miller) gel.

Author information

1
1 Department of Pharmaceutical Sciences, 67883 State University of Ponta Grossa , Paraná, Brazil.
2
2 Department of Medicine, 67883 State University of Ponta Grossa , Paraná, Brazil.
3
3 Department of Structural, Molecular and Genetic Biology, 67883 State University of Ponta Grossa , Paraná, Brazil.

Abstract

A new alginate dressing with Aloe vera gel was developed and used to study its cutaneous healing effect in vivo by surgical wounds in Wistar rats. The aloe-alginate film was characterized by Fourier-transform infrared spectroscopy, mechanical properties, scanning electron microscopy, hydration rate, and calcium release. The aloe-alginate film demonstrated desirable physical and mechanical characteristics for wound dressing application. The animals were divided in three groups (n = 20): gauze bandage, alginate film, and aloe-alginate film. The histological analysis on the 3rd, 7th, 14th, and 22nd days after the treatment showed that the aloe-alginate films modulated the inflammatory phase and decreased the quantity of macrophages when compared to the alginate film group and the control (gauze bandage). The evaluation of collagen fibers showed a decrease in type III and increase in type I fibers on group treated with aloe-alginate film suggesting an improvement in the progression of the healing process.

KEYWORDS:

Alginate; Aloe vera; dressing; film; healing

PMID:
29380661
DOI:
10.1177/0885328218754615

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