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J Pharm Pharmacol. 2018 Apr;70(4):559-565. doi: 10.1111/jphp.12865. Epub 2018 Jan 30.

Effects of S-1-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats.

Author information

1
Central Research Institute, Wakunaga Pharmaceutical Co. Ltd., Akitakata-shi, Hiroshima, Japan.

Abstract

OBJECTIVES:

This study was designed to investigate the antihypertensive effect of S-1-propenylcysteine, a characteristic sulfur compound in aged garlic extract, using a hypertensive rat model.

METHODS:

The blood pressure and tail blood flow of both spontaneously hypertensive rats and control Wistar Kyoto rats were measured by the tail-cuff method and the noncontact laser Doppler method, respectively, at various times after single oral administration of a test compound for 24 h.

KEY FINDINGS:

Treatment with S-1-propenylcysteine (6.5 mg/kg BW) significantly decreased the systolic blood pressure of spontaneously hypertensive rat approximately 10% at 3 h after administration, and thereafter, the systolic blood pressure gradually returned to the baseline level in 24 h. The effect of S-1-propenylcysteine was dose-dependent and was maximal at the dose of 6.5 mg/kg BW at 3 h. However, the other compounds such as S-allylcysteine and S-allylmercaptocysteine in aged garlic extract were ineffective. In addition, S-1-propenylcysteine had no effect on systolic blood pressure of control Wistar Kyoto rats. Furthermore, S-1-propenylcysteine significantly increased the blood flow at 3 h after administration at the dose of 6.5 mg/kg BW.

CONCLUSIONS:

S-1-propenylcysteine is a key constituent of aged garlic extract responsible for its antihypertensive effect, and the effect of S-1-propenylcysteine involves the improvement in peripheral circulation.

KEYWORDS:

S-1-propenylcysteine; aged garlic extract; hypertension; peripheral circulation; spontaneously hypertensive rats

PMID:
29380376
DOI:
10.1111/jphp.12865
[Indexed for MEDLINE]

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