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Curr HIV/AIDS Rep. 2018 Feb;15(1):49-59. doi: 10.1007/s11904-018-0377-0.

Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring.

Author information

1
Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Medicine/Infectious Diseases, 12700 E 19th Ave., B168, Aurora, CO, 80045, USA. jose.castillo-mancilla@ucdenver.edu.
2
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Abstract

PURPOSE OF REVIEW:

In this review, we present new developments in antiretroviral adherence, focusing on pharmacological measures and real-time adherence monitoring. In addition, new strategies on how to incorporate these new measures into research and clinical care are proposed.

RECENT FINDINGS:

Antiretroviral drug concentrations in hair and dried blood spots are two novel pharmacological measures of cumulative drug adherence and exposure that have been recently evaluated in HIV treatment and pre-exposure prophylaxis. Real-time adherence monitoring using electronic devices has also proven highly informative, feasible, and well accepted, offering the possibility for an immediate intervention when non-adherence is detected. Both approaches offer considerable advantages over traditional adherence measures in predicting efficacy. New methods to objectively monitor adherence in real-time and over long time periods have been developed. Further research is required to better understand how these measures can optimize adherence and, ultimately, improve clinical outcomes in HIV treatment and prevention.

KEYWORDS:

ART Adherence; Dried blood spots; Hair drug levels; Real-time adherence monitoring

PMID:
29380227
PMCID:
PMC5876155
[Available on 2019-02-01]
DOI:
10.1007/s11904-018-0377-0

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