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Arch Med Sci. 2018 Jan;14(1):1-21. doi: 10.5114/aoms.2018.72238. Epub 2017 Dec 19.

Hypercholesterolaemia - practical information for non-specialists.

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Cardiovascular Research Group, Faculty of Biology, Medicine & Health, University of Manchester, UK.
Cardiovascular Trials Unit, University Department of Medicine, Manchester University NHS Foundation Trust, Manchester, UK.
Department of Medicine, University of Duhok, Duhok, Kurdistan region, Iraq.
Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Manchester, UK.
Immunohematology and Transfusion Medicine, Department of Molecular Medicine, University of Rome, Rome, Italy.
Weill Cornell Medicine-Qatar, Doha, Qatar.
Department of Hypertension, Medical University of Lodz, Poland.


Hypercholesterolaemia is amongst the most common conditions encountered in the medical profession. It remains one of the key modifiable cardiovascular risk factors and there have been recent advances in the risk stratification methods and treatment options available. In this review, we provide a background into hypercholesterolaemia for non-specialists and consider the merits of the different risk assessment tools available. We also provide detailed considerations as to: i) when to start treatment, ii) what targets to aim for and iii) the role of low density lipoprotein cholesterol.


cardiovascualr risk; hypercholesterolaemia; lipid disorders; low density lipoprotein cholesterol; practical recommendations

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