Effect of CMS and cocaine on Hippocampal CRH expression. Mice were exposed to CMS or no stress for 4 weeks, then treated with cocaine (15 mg/kg) or saline for 1 week in the CPP protocol. Letters above bars: one-way ANOVA with Bonferroni means separation test comparing treatments within mouse strain [abc] or treatments between strains [*]. (A) Corticotropin releasing hormone (CRH: WT: [F(3,16) = 13.34, p = 0.0001]; Sub: [F(3,16) = 11.83, p = 0.0002]; Dom: [F(3,16) = 12.63, p = 0.0002]; CMS: [F(2,12) = 7.219, p = 0.0087]). (B) CRH receptor 1 (CRHR1: WT: [F(3,16) = 7.596, p = 0.0022]; Sub: [F(3,16) = 26.11, p < 0.0001]; Dom: [F(3,16) = 19.39, p < 0.0001]).