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Nat Commun. 2018 Jan 29;9(1):422. doi: 10.1038/s41467-017-02751-2.

Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory.

Author information

1
Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California, Los Angeles, CA, 90095, USA.
2
Department of Psychology; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, 90095, USA.
3
Department of Neurobiology, Tel Aviv University, Tel Aviv, 69978, Israel.
4
Institute for Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), GR, 70013, Heraklion, Greece.
5
Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, CA, 90095, USA.
6
Institute for Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), GR, 70013, Heraklion, Greece. poirazi@imbb.forth.gr.
7
Department of Neurobiology; Integrative Center for Learning and Memory; Brain Research Institute, University of California, Los Angeles, CA, 90095, USA. silvaa@mednet.ucla.edu.
8
Department of Psychology; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, 90095, USA. silvaa@mednet.ucla.edu.

Abstract

Modeling studies suggest that clustered structural plasticity of dendritic spines is an efficient mechanism of information storage in cortical circuits. However, why new clustered spines occur in specific locations and how their formation relates to learning and memory (L&M) remain unclear. Using in vivo two-photon microscopy, we track spine dynamics in retrosplenial cortex before, during, and after two forms of episodic-like learning and find that spine turnover before learning predicts future L&M performance, as well as the localization and rates of spine clustering. Consistent with the idea that these measures are causally related, a genetic manipulation that enhances spine turnover also enhances both L&M and spine clustering. Biophysically inspired modeling suggests turnover increases clustering, network sparsity, and memory capacity. These results support a hotspot model where spine turnover is the driver for localization of clustered spine formation, which serves to modulate network function, thus influencing storage capacity and L&M.

PMID:
29379017
PMCID:
PMC5789055
DOI:
10.1038/s41467-017-02751-2
[Indexed for MEDLINE]
Free PMC Article

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