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BMC Public Health. 2018 Jan 29;18(1):186. doi: 10.1186/s12889-018-5044-2.

Interrupting seasonal transmission of Schistosoma haematobium and control of soil-transmitted helminthiasis in northern and central Côte d'Ivoire: a SCORE study protocol.

Author information

1
Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, 22 BP 770, Abidjan, 22, Côte d'Ivoire. tianbyth@yahoo.fr.
2
Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, 01 BP 1303, Abidjan, 01, Côte d'Ivoire. tianbyth@yahoo.fr.
3
Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, 22 BP 770, Abidjan, 22, Côte d'Ivoire.
4
Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, 01 BP 1303, Abidjan, 01, Côte d'Ivoire.
5
Swiss Tropical and Public Health Institute, P.O. Box, CH-4002, Basel, Switzerland.
6
University of Basel, P.O. Box, CH-4003, Basel, Switzerland.
7
Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, Natural History Museum, Cromwell Road, London, SW7 5BD, United Kingdom.
8
Programme National de Lutte contre les Maladies Tropicales Négligées à Chimiothérapie Préventive, Ministère de la Santé et de l'Hygiène Publique, 06 BP 6394, Abidjan, 06, Côte d'Ivoire.
9
Swiss Tropical and Public Health Institute, P.O. Box, CH-4002, Basel, Switzerland. juerg.utzinger@swisstph.ch.
10
University of Basel, P.O. Box, CH-4003, Basel, Switzerland. juerg.utzinger@swisstph.ch.

Abstract

BACKGROUND:

To achieve a world free of schistosomiasis, the objective is to scale up control and elimination efforts in all endemic countries. Where interruption of transmission is considered feasible, countries are encouraged to implement a comprehensive intervention package, including preventive chemotherapy, information, education and communication (IEC), water, sanitation and hygiene (WASH), and snail control. In northern and central Côte d'Ivoire, transmission of Schistosoma haematobium is seasonal and elimination might be achieved. In a cluster-randomised trial, we will assess different treatment schemes to interrupt S. haematobium transmission and control soil-transmitted helminthiasis over a 3-year period. We will compare the impact of (i) arm A: annual mass drug administration (MDA) with praziquantel and albendazole before the peak schistosomiasis transmission season; (ii) arm B: annual MDA after the peak schistosomiasis transmission season; (iii) arm C: two yearly treatments before and after peak schistosomiasis transmission; and (iv) arm D: annual MDA before peak schistosomiasis transmission, coupled with chemical snail control using niclosamide.

METHODS/DESIGN:

The prevalence and intensity of S. haematobium and soil-transmitted helminth infections will be assessed using urine filtration and Kato-Katz thick smears, respectively, in six administrative regions in northern and central parts of Côte d'Ivoire. Once a year, urine and stool samples will be collected and examined from 50 children aged 5-8 years, 100 children aged 9-12 years and 50 adults aged 20-55 years in each of 60 selected villages. Changes in S. haematobium and soil-transmitted helminth prevalence and intensity will be assessed between years and stratified by intervention arm. In the 15 villages randomly assigned to intervention arm D, intermediate host snails will be collected three times per year, before niclosamide is applied to the selected freshwater bodies. The snail abundance and infection rates over time will allow drawing inference on the force of transmission.

DISCUSSION:

This cluster-randomised intervention trial will elucidate whether in an area with seasonal transmission, the four different treatment schemes can interrupt S. haematobium transmission and control soil-transmitted helminthiasis. Lessons learned will help to guide schistosomiasis control and elimination programmes elsewhere in Africa.

TRIAL REGISTRATION:

ISRCTN ISRCTN10926858 . Registered 21 December 2016. Retrospectively registered.

KEYWORDS:

Bulinus spp.; Chemical snail control; Côte d’Ivoire; Mass drug administration; Niclosamide; Praziquantel; Schistosoma haematobium; Seasonal transmission; Soil-transmitted helminthiasis

PMID:
29378542
PMCID:
PMC5789673
DOI:
10.1186/s12889-018-5044-2
[Indexed for MEDLINE]
Free PMC Article

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