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Rev Med Virol. 2018 Mar;28(2). doi: 10.1002/rmv.1968. Epub 2018 Jan 29.

Molecular epidemiology of respiratory syncytial virus.

Author information

1
School of Public Health, The University of Sydney, Sydney, Australia.
2
Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
3
Marie Bashir Institute of Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia.
4
Discipline of Child and Adolescent Health, The University of Sydney, Sydney, Australia.
5
Department of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, Sydney, Australia.

Abstract

Respiratory syncytial virus (RSV) is a major cause of viral acute respiratory tract infections in young children. The virus is characterised by distinct seasonality that is dependent upon the latitude and its ability to cause reinfection. Respiratory syncytial virus demonstrates a complex molecular epidemiology pattern as multiple strains and/or genotypes cocirculate during a single epidemic. Previous studies have investigated the relationship between RSV genetic diversity, reinfection, and clinical features. Here, we review the evidence behind this relationship together with the impact that the advancement of whole genome sequencing will have upon our understanding and the need for reconsidering the classification of RSV genotypes.

KEYWORDS:

genotype; molecular epidemiology; respiratory syncytial virus; whole-genome

PMID:
29377415
DOI:
10.1002/rmv.1968
[Indexed for MEDLINE]

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