Phosphinoyl Radical-Initiated 1,2-Bifunctional Thiocyanodiphenylphosphinoylation of Alkenes

Ze-Kun Tao; Cheng-Kun Li; Pei-Zhi Zhang; Adedamola Shoberu; Jian-Ping Zou; Wei Zhang

doi:10.1021/acs.joc.7b02929

Phosphinoyl Radical-Initiated 1,2-Bifunctional Thiocyanodiphenylphosphinoylation of Alkenes

J Org Chem. 2018 Feb 16;83(4):2418-2424. doi: 10.1021/acs.joc.7b02929. Epub 2018 Feb 5.

Authors

Ze-Kun Tao¹, Cheng-Kun Li¹, Pei-Zhi Zhang¹, Adedamola Shoberu¹, Jian-Ping Zou¹, Wei Zhang²

Affiliations

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Soochow University , Jiangsu 215123, China.
² Department of Chemistry, University of Massachusetts Boston , Boston, Massachusetts 02125, United States.

PMID: 29376357
DOI: 10.1021/acs.joc.7b02929

Abstract

1,2-Bifuctional thiocyanodiphenylphosphinoylation of alkenes is established through the phosphinoyl radical addition followed by Cu-catalyzed thiocyanation. This one-pot reaction is applicable to a range of aromatic, aliphatic, and cyclic alkenes to afford thiocyanodiphenylphosphinoylated compounds in satisfactory yields.

Publication types

Research Support, Non-U.S. Gov't