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World J Gastroenterol. 2018 Jan 14;24(2):248-256. doi: 10.3748/wjg.v24.i2.248.

Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection.

Author information

1
Vietnamese-German Center of Excellence in Medical Research, Hanoi, Vietnam.
2
Institute of Tropical Medicine, University of Tübingen, Tübingen 72074, Germany.
3
Vietnamese-German Center of Excellence in Medical Research, Hanoi, Vietnam. velavan@medizin.uni-tuebingen.de.

Abstract

AIM:

To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.

METHODS:

Four IFR5 SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B (CHB). n = 99; liver cirrhosis (LC), n = 131; hepatocellular carcinoma (HCC), n = 149] and in 242 healthy controls by direct sequencing and TaqMan real-time PCR assays.

RESULTS:

Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262T and rs10488630G contributed to an increased risk of liver cirrhosis (LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients (OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups (LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin.

CONCLUSION:

Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections.

KEYWORDS:

Hepatitis B virus infection; IFR5 haplotypes; IFR5 polymorphisms; IRF5; Liver diseases

PMID:
29375210
PMCID:
PMC5768943
DOI:
10.3748/wjg.v24.i2.248
[Indexed for MEDLINE]
Free PMC Article

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