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Environ Health Perspect. 2017 Dec 15;125(12):127002. doi: 10.1289/EHP2062.

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study.

Author information

1
Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA
2
Department of Epidemiology, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
3
Center for Molecular Epidemiology at Dartmouth, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
4
Department of Microbiology and Immunology and Norris Cotton Cancer Center, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
5
Norris Cotton Cancer Center, Dartmouth–Hitchcock Medical Center, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
6
Department of Biomedical Data Science, Dartmouth Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA
7
Department of Population Health, New York University School of Medicine, New York, New York, USA

Abstract

BACKGROUND:

Arsenic (As) exposure has been associated with increased risk for cardiovascular disease (CVD) and with biomarkers of potential CVD risk and inflammatory processes. However, few studies have evaluated the effects of As on such biomarkers in U.S. populations, which are typically exposed to low to moderate As concentrations.

OBJECTIVES:

We investigated associations between As exposures and biomarkers relevant to inflammation, oxidative stress, and CVD risk in a subset of participants from the New Hampshire Health Study, a population with low to moderate As exposure (n=418).

METHODS:

Associations between toenail As, total urine As (uAs), and %uAs metabolites [monomethyl (%uMMAV), dimethyl (%uDMAV), and inorganic (%iAs) species] and plasma biomarkers, including soluble plasma vascular and cellular adhesion molecules (VCAM-1 and ICAM-1, respectively), matrix metalloproteinase-9 (MMP-9), tumor necrosis factor-α, plasminogen activator inhibitor-1 (PAI-1), and urinary oxidative stress marker 15-F2t-isoprostane (15-F2t-IsoP), were evaluated using linear regression models.

RESULTS:

Covariate-adjusted estimates of associations with a doubling of urinary As suggested an 8.8% increase in 15-F2t-IsoP (95% CI: 3.2, 14.7), and a doubling of toenail As was associated with a 1.7% increase in VCAM-1 (95% CI: 0.2, 3.2). Additionally, a 5% increase in %uMMA was associated with a 7.9% increase in 15-F2t-IsoP (95% CI: 2.1, 14.1), and a 5% increase in %uDMA was associated with a 2.98% decrease in 15-F2t-IsoP [(95% CI: -6.1, 0.21); p=0.07]. However, in contrast with expectations, a doubling of toenail As was associated with a 2.3% decrease (95% CI: -4.3, -0.3) in MMP-9, and a 5% increase in %uMMA was associated with a 7.7% decrease (95% CI: -12.6, -2.5) in PAI-1.

CONCLUSION:

In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062.

PMID:
29373859
PMCID:
PMC5963594
DOI:
10.1289/EHP2062
[Indexed for MEDLINE]
Free PMC Article

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