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Clin Oral Investig. 2018 Sep;22(7):2511-2518. doi: 10.1007/s00784-018-2347-8. Epub 2018 Jan 25.

Lactobacillus rhamnosus intake can prevent the development of Candidiasis.

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Bioscience Basic Institute, University of Taubaté, Av. Tiradentes, 500 Bom Conselho, Taubaté, SP, 12030-180, Brazil.
Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, Univ. Estadual Paulista, UNESP, Av. Eng. Francisco José Longo, 777 Jardim Sao Dimas, São José dos Campos, SP, 12245-000, Brazil.
Bioscience Basic Institute, University of Taubaté, Av. Tiradentes, 500 Bom Conselho, Taubaté, SP, 12030-180, Brazil.



This study aimed to investigate the influence of Lactobacillus rhamnosus intake on the development of candidiasis and cytokines release.


Candida suspensions were inoculated into the oral cavity of experimentally immunosuppressed mice for candidiasis induction. The animals were divided into experimental groups: candidiasis with no probiotic intake (F), candidiasis with probiotic intake during Candida inoculation (FP), and candidiasis with probiotic intake 14 days before inoculation with Candida (FPP); and control groups: (C), (CP), and (CPP) without inducing candidiasis with probiotic intake in the same manner as groups F, FP, and FPP, respectively. After these periods, samples were collected from the oral cavity for yeast counts and, after euthanasia, the tongues of the animals were removed for histological analysis. Sera samples were also collected for analysis of IL-1 beta, TNF-alpha, INF-gamma, IL-12, IL-4, and IL-10.


FP group showed lower Candida counts in the oral cavity, and the presence of Candida was almost not detected in FPP group. In tissues, the counts of fungi were significantly lower in FPP group, followed by FP. Groups that consumed probiotics also had lower histological and inflammatory infiltrates compared to F. Cytokines analysis demonstrated low concentrations of TNF-α, IL-12, IL-4, and IL-10 in all the groups, and no statistical difference between them. The production of IL-6 could be better detected, and the experimental groups that consumed the probiotic showed significant lower levels of this cytokine.


The results suggest that L. rhamnosus intake, especially preventively, may avoid or decrease the development of candidiasis in immunosuppressed mice.


This work adds scientific evidences that probiotics intake can avoid the development of candidiasis.


Candida; Cytokine; Lactobacillus rhamnosus; Probiotics


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