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Drug Discov Today. 2018 Apr;23(4):830-847. doi: 10.1016/j.drudis.2018.01.038. Epub 2018 Jan 31.

Methodologies for assessing the acceptability of oral formulations among children and older adults: a systematic review.

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Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
CLINSEARCH, 110 Avenue Pierre Brossolette, 92240, Malakoff, France.
Jenny Walsh Consulting Ltd, BioCity Nottingham, Pennyfoot Street, Nottingham, NG1 1GF, UK.
Department of Pharmacy, Pharmacology and Postgraduate Medicine, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, AL10 9AB, UK. Electronic address:


Acceptability of medicinal products in children and older populations is pivotal in ensuring adherence and therapeutic outcomes. This review systematically identifies studies reporting on formulation aspects of oral medications that affect their acceptability in these patient groups. Particular emphasis is placed on the evaluation of the methodologies employed in the studies. Sixty-eight studies were included for analysis, with 51 (75%) in children and 17 (25%) in older populations. The studies evaluated a range of oral formulations; however, the methodologies used differ considerably in participants' characteristics, study settings, tools, acceptability definitions and criteria. It is evident that there is a lack of standardisation in study design as well as the assessment methods used in assessing acceptability of medicines in children and older populations.

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