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PLoS One. 2018 Jan 25;13(1):e0191798. doi: 10.1371/journal.pone.0191798. eCollection 2018.

Hepatitis E prevalence in a sexual high-risk population compared to the general population.

Author information

1
Department of Sexual Health, Infectious Diseases and Environmental Health, Public Health Service (GGD) South Limburg, Geleen, the Netherlands.
2
Department of Medical Microbiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands.
3
Department of Family Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands.

Abstract

Transmission routes of the hepatitis E virus (HEV) are under debate. Here, we studied possible sexual transmission by comparing HEV prevalence in a Dutch sexual high-risk population (n = 1,482) with that in a general population (n = 1,487) while assessing sociodemographic and sexual risk factors. Overall prevalence of anti-HEV IgG of 18.9% (n = 562) was, adjusting for confounders, similar between the two populations (p = 0.44). Prevalence was higher with each year's increase in age (adjusted OR: 1.03, 95%CI: 1.02-1.04, p<0.01), among men (adjusted OR: 1.24, 95%CI: 1.02-1.50, p = 0.03) and among individuals diagnosed with sexually transmitted infections (adjusted OR: 1.60, 95%CI: 1.02-2.49, p = 0.04). Our results only hint at the possibility of a sexual transmission route for HEV given higher rates in those with chlamydia and/or gonorrheal infections. Sexual transmission is not a dominant transmission route, as its prevalence was not higher for the sexual high-risk population than for the general population.

PMID:
29370254
PMCID:
PMC5784977
DOI:
10.1371/journal.pone.0191798
[Indexed for MEDLINE]
Free PMC Article

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