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PLoS Genet. 2018 Jan 25;14(1):e1007118. doi: 10.1371/journal.pgen.1007118. eCollection 2018 Jan.

Taking cohesin and condensin in context.

Yuen KC1,2, Gerton JL1,3,4.

Author information

1
Stowers Institute for Medical Research, Kansas City, Missouri, United States of America.
2
Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America.
3
Department of Biochemistry and Molecular Biology, University of Kansas School of Medicine, Kansas City, Kansas, United States of America.
4
University of Kansas Cancer Center, Kansas City, Kansas, United States of America.

Abstract

Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome. We review adaptor proteins for SMC complexes and how these adaptors may capture SMC complexes following loop extrusion to provide a framework for chromosome organization.

PMID:
29370184
PMCID:
PMC5784890
DOI:
10.1371/journal.pgen.1007118
[Indexed for MEDLINE]
Free PMC Article

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