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BMC Womens Health. 2018 Jan 24;18(1):25. doi: 10.1186/s12905-017-0493-9.

Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana.

Author information

1
Centre d'Investigation Clinique Antilles-Guyane, CIC INSERM 1424, Centre hospitalier de Cayenne, Ave des Flamboyants, 97300, Cayenne, French Guiana.
2
Laboratoire de Virologie, CHU de la Martinique, Fort de France, Martinique.
3
Laboratoire d'anatomopathologie, CHU de la Martinique, Fort de France, Martinique.
4
Service de Gynécologie Obstétrique, Centre hospitalier de Cayenne, Cayenne, French Guiana.
5
AGDOC Association de Dépistage Organisé des Cancers de Guyane, Cayenne, French Guiana.
6
Département des Centres délocalisés de prévention et de soins, Centre Hospitalier de Cayenne, 97300, Cayenne, French Guiana.
7
Service de Gynécologie Obstétrique, Centre Hospitalier de l'Ouest Guyanais, Saint Laurent du Maroni, Cayenne, French Guiana.
8
Laboratoire des Interactions Virus-Hôtes, Institut Pasteur de la Guyane, Cayenne, French Guiana.
9
Centre d'Investigation Clinique Antilles-Guyane, CIC INSERM 1424, Centre hospitalier de Cayenne, Ave des Flamboyants, 97300, Cayenne, French Guiana. mathieu.nacher@ch-cayenne.fr.
10
EA 3593, Ecosystèmes Amazoniens et Pathologie Tropicale, Université de Guyane, Cayenne, French Guiana. mathieu.nacher@ch-cayenne.fr.

Abstract

BACKGROUND:

Cervical cancer prevention using cervical cytology is insufficiently sensitive, a significant proportion of HPV-infected women having normal cytology. The objective of the present study was to try to identify factors associated with abnormal cytology in HPV-infected women living in remote areas of French Guiana.

METHODS:

A study was conducted in women aged 20-65 years having HPV infections confirmed by HPV DNA detection using the GREINER-BIO-ONE kit. In addition to HPV testing, cytology was performed and classified as normal or abnormal. Demographic and life history variables, and infecting genotypes were compared between the normal and abnormal cytology groups.

RESULTS:

None of the demographic and life history variables were associated with cytology results. HPV genotype 53 was significantly associated with absence of cytological abnormalities whereas HPV 52, 58, 16 and perhaps 33 and 66 were independently associated with a greater risk of cytological abnormalities. When grouping HPV genotypes in different species, only species 9 (HPV 16, 31, 33, 35, 52, 58, 67) was significantly associated with abnormal cytology AOR = 5.1 (95% CI = 2.3-11.2), P < 0.001.

CONCLUSIONS:

It was not possible to predict which HPV-infected women will have cytological abnormalities or notfrom anamnesis. In this study HPV 53 seemed more benign than other HPV genotypes. On the contrary, species n°9, containing 5 of the genotypes contained in the nonavalent HPV vaccine, was significantly associated with more cytological abnormalities. HPV testing and vaccination with the nonavalent vaccine should be implemented in these remote parts of French Guiana.

PMID:
29368607
PMCID:
PMC5784667
DOI:
10.1186/s12905-017-0493-9
[Indexed for MEDLINE]
Free PMC Article

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