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Indian J Pediatr. 2018 Jul;85(7):493-497. doi: 10.1007/s12098-018-2608-1. Epub 2018 Jan 25.

Effect of Folic Acid Supplementation on Seizure Control in Epileptic Children Receiving Long Term Antiepileptic Therapy.

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Department of Pediatrics, Dr. S. N. Medical College, Jodhpur, Rajasthan, India.
Department of Pediatrics, Dr. S. N. Medical College, Jodhpur, Rajasthan, India.
Department of Pathology, Rog Nidan Seva Diagnostic Centre, Jodhpur, Rajasthan, India.



To evaluate the effect of folic acid supplementation on seizure control in folate deficient children receiving long term antiepileptic therapy.


In a prospective interventional study, 140 children between age group 6 mo to 180 mo fulfilling the inclusion criteria were enrolled in study group, from October 2015 through November 2016. On the basis of serum folate, study group was divided into two subgroups by non randomization: Group A (<10 ng/ml) given folic acid supplementation for 3 mo and Group B (>10 ng/ml) was not supplemented. Response to folic acid supplementation in group A was compared with group B in terms of change in blood folate levels, frequency and duration of seizures after three months.


Mean age of study group was 73.58 ± 46.89 mo (72.14% boys and 27.85% girls). 67.85% children were in group A and 32.14% in group B. On 3 mo follow up, children supplemented with folic acid (Group A) had significant fall in mean seizure frequency while in non-supplemented children (Group B), no significant change was seen (p value <0.05). Similar reduction in duration of seizure episode was seen in group A as compared to group B. Serum and RBC folate levels improved from baseline in group A, while in group B there was significant fall in folate levels.


Folate deficiency is common in epileptic children on long term antiepileptic drugs (AEDs), contributes to poor seizure control and should be considered in the etiologic differentials of drug resistant epilepsy. Folate supplementation improves seizure control in these children.


Childhood epilepsy; Folic acid; Refractory; Seizure

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