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Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(6):408-415. doi: 10.2177/jsci.40.408.

[Intestinal immune response is regulated by gut microbe].

[Article in Japanese]

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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine.


  Human Intestine has a diverse population of bacteria which induces pathogens to disrupt not only the intestinal homeostasis but whole body immune systems. Dysbiosis, the abnormal proliferation and reduction of the microbiota, breaks down the homeostasis of the immunity and metabolisms in the host. The evolution of the microbiota analysis technology contributed to reveal the molecular biological complex interaction between the microbiota and its host systemically as well as locally. Because several diseases are caused by the dysbiosis, fecal transplantation would be the new therapeutic target for them. It has been investigated in some intestinal diseases such as CD infection, or inflammatory bowel disease. Here, we review these symbiotic interactions and the current state for the clinical application.


fecal microbiota transplantation; immunity; inflammatory bowel disease; microbiota

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