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Sci Transl Med. 2018 Jan 24;10(425). pii: eaan2742. doi: 10.1126/scitranslmed.aan2742.

Miniaturized neural system for chronic, local intracerebral drug delivery.

Author information

1
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2
Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4
McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5
IQS School of Engineering, Ramon Llull University, 08017 Barcelona, Spain.
6
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. mjcima@mit.edu rlanger@mit.edu.
7
Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Recent advances in medications for neurodegenerative disorders are expanding opportunities for improving the debilitating symptoms suffered by patients. Existing pharmacologic treatments, however, often rely on systemic drug administration, which result in broad drug distribution and consequent increased risk for toxicity. Given that many key neural circuitries have sub-cubic millimeter volumes and cell-specific characteristics, small-volume drug administration into affected brain areas with minimal diffusion and leakage is essential. We report the development of an implantable, remotely controllable, miniaturized neural drug delivery system permitting dynamic adjustment of therapy with pinpoint spatial accuracy. We demonstrate that this device can chemically modulate local neuronal activity in small (rodent) and large (nonhuman primate) animal models, while simultaneously allowing the recording of neural activity to enable feedback control.

PMID:
29367347
PMCID:
PMC6746310
DOI:
10.1126/scitranslmed.aan2742
[Indexed for MEDLINE]
Free PMC Article

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