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J Clin Microbiol. 2018 Mar 26;56(4). pii: e01934-17. doi: 10.1128/JCM.01934-17. Print 2018 Apr.

CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests.

Author information

1
Accelerate Diagnostics, Tucson, Arizona, USA rhumphries@axdx.com.
2
Wockhardt, Morton Grove Pharmaceuticals, Morton Grove, Illinois, USA.
3
Clinical Microbiology Laboratory, Children's Hospital of Pittsburgh of UPMC and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
4
JMI Laboratories, North Liberty, Iowa, USA.
5
Provincial Laboratory for Public Health, Edmonton, Alberta, Canada.
6
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
7
Department of Pathology & Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
8
Laboratory Specialists, Inc., Westlake, Ohio, USA.
9
Beckman-Coulter, West Sacramento, California, USA.

Abstract

Effective evaluations of antimicrobial susceptibility tests (ASTs) require robust study design. The Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antimicrobial Susceptibility Testing has recognized that many published studies reporting the performance of commercial ASTs (cASTs) suffer from major design and/or analysis flaws, rendering the results difficult or impossible to interpret. This minireview outlines the current consensus of the Methods Development and Standardization Working Group of the CLSI Subcommittee on Antimicrobial Susceptibility Testing regarding best practices for systematic evaluation of the performance of an AST, including the analysis and presentation of essential data intended for publication.

KEYWORDS:

CLSI; antimicrobial susceptibility testing; evaluations

PMID:
29367292
PMCID:
PMC5869819
DOI:
10.1128/JCM.01934-17
[Indexed for MEDLINE]
Free PMC Article

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