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Trends Genet. 2018 Mar;34(3):167-170. doi: 10.1016/j.tig.2017.12.009. Epub 2018 Jan 30.

The Definition of Open Reading Frame Revisited.

Author information

1
Department of Bioinformatics, Friedrich Schiller University Jena, Ernst-Abbe-Platz 2, 07743 Jena, Germany.
2
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstra├če 11, 07745 Jena, Germany.
3
Department of Bioinformatics, Friedrich Schiller University Jena, Ernst-Abbe-Platz 2, 07743 Jena, Germany. Electronic address: stefan.schu@uni-jena.de.

Abstract

The term open reading frame (ORF) is of central importance to gene finding. Surprisingly, at least three definitions are in use. We discuss several molecular biological and bioinformatics aspects, and we recommend using the definition in which an ORF is bounded by stop codons.

KEYWORDS:

definition; gene finding; open reading frame; stop codon

PMID:
29366605
DOI:
10.1016/j.tig.2017.12.009
[Indexed for MEDLINE]

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