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Respirology. 2018 Jun;23(6):576-582. doi: 10.1111/resp.13239. Epub 2018 Jan 24.

Vitamin D and respiratory health in the Busselton Healthy Ageing Study.

Mulrennan S1,2,3, Knuiman M3,4, Walsh JP2,3,5, Hui J3,4,6, Hunter M3,4, Divitini M4, Zhu K2,5, Cooke BR6, Musk AWB1,2,3,4, James A2,3,7.

Author information

1
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia.
2
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia.
3
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia.
4
School of Population and Global Health, University of Western Australia, Perth, WA, Australia.
5
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA, Australia.
6
PathWest Laboratory Medicine, Perth, WA, Australia.
7
Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia.

Abstract

BACKGROUND AND OBJECTIVE:

The relationship between vitamin D and respiratory disease was examined by cross-sectional analysis of a large community-based sample.

METHODS:

Serum 25-hydroxyvitamin D (25OHD) and history of respiratory disease, symptoms (recorded by questionnaire) and spirometry were measured in 5011 adults aged 45-69 years. Adjustments were made for age, sex, season and smoking (Model A), plus body mass index (BMI) and physical activity level (Model B), plus history of chronic diseases (Model C).

RESULTS:

Mean (SD) age was 58 (SD 6) years with 45% males, 10% current smokers and 12% taking vitamin D supplements. The prevalence of 25OHD level <50 nmol/L was 8.0%. In all the three models, 25OHD <50 nmol/L was significantly associated with asthma (Model C: odds ratio (OR): 1.32; 95% CI: 1.00, 1.73), bronchitis (1.54; 1.17, 2.01), wheeze (1.37; 1.10, 1.71) and chest tightness (1.42; 1.10, 1.83). Participants with vitamin D level > 100 nmol/L had higher forced vital capacity (FVC) in all the three models (1.17% higher, compared with the 50-100 nmol/L group in Model C).

CONCLUSION:

Low levels of serum 25OHD were independently associated with asthma, bronchitis, wheeze and chest tightness after three levels of adjustment for potential confounders. Higher vitamin D levels were associated with higher levels of lung function.

KEYWORDS:

lung function; respiratory disease; serum 25-hydroxyvitamin D; vitamin D

PMID:
29365367
DOI:
10.1111/resp.13239
[Indexed for MEDLINE]
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