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Nature. 2018 Feb 1;554(7690):56-61. doi: 10.1038/nature25473. Epub 2018 Jan 24.

The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms.

Author information

1
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.
2
Heidelberg Institute for Theoretical Studies, Schloss-Wolfsbrunnenweg 35, 69118 Heidelberg, Germany.
3
The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
4
Deep Sequencing Group, BIOTEC/Center for Regenerative Therapies Dresden, Cluster of Excellence at TU Dresden, Fetscherstraße 105, 01307 Dresden, Germany.
5
Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38 01187 Dresden, Germany.

Abstract

The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.

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PMID:
29364871
PMCID:
PMC5797480
DOI:
10.1038/nature25473
[Indexed for MEDLINE]
Free PMC Article

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