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Nature. 2018 Jan 24;553(7689):437-445. doi: 10.1038/nature25032.

The rise of three-dimensional human brain cultures.

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1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.


Pluripotent stem cells show a remarkable ability to self-organize and differentiate in vitro in three-dimensional aggregates, known as organoids or organ spheroids, and to recapitulate aspects of human brain development and function. Region-specific 3D brain cultures can be derived from any individual and assembled to model complex cell-cell interactions and to generate circuits in human brain assembloids. Here I discuss how this approach can be used to understand unique features of the human brain and to gain insights into neuropsychiatric disorders. In addition, I consider the challenges faced by researchers in further improving and developing methods to probe and manipulate patient-derived 3D brain cultures.

[Indexed for MEDLINE]

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