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J Cosmet Dermatol. 2018 Jun;17(3):454-460. doi: 10.1111/jocd.12500. Epub 2018 Jan 24.

Comparative efficacy of two anti-aging products containing retinyl palmitate in healthy human volunteers.

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Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.
Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.



No study yet described the comparative efficacy of two over-the-counter (OTC) anti-aging products in Asian subjects using the techniques involving analysis of living skin.


We sought to evaluate the anti-aging efficacy of two commercial formulations containing retinyl palmitate using a high-resolution UVA video camera.


Total 11 healthy male volunteers, agreed to participate in this single-blind split-face design study with the mean age of 25.5 years. Every night, volunteers applied one type of cream on the left side and other type of cream on the right side of the face, as directed according to the study design for 60 days. Measurements of the parameters were taken at 0, 1st, 7th, 15th, 30th, and 60th day of study period using noninvasive UVA video camera Visioscan® VC98. Cream applied on right side of the face labeled as "R" and on the left side as "L."


Sixty-day use of the creams showed significant improvement in SELS parameters of the skin. Percent change in skin wrinkling (SEw) parameter calculated after 60 days was -6.68% after applying cream R and -8.27% after applying cream L.


We concluded that constituents in both creams have potentially influenced skin surface parameters, thus indicating that, these creams as a better option to lessen the effects of aging on facial skin on long-term application.


analysis of otc creams; anti-aging; facial wrinkles; retinyl palmitate; visioscan

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